Diabetes mellitus is a major world health problem. Treatment and management of diabetics is a very significant issue for governments, society and both pharmacists and pharmaceutical companies. Completing this assignment will help you to gain a deeper understanding of diabetes mellitus.
The length of this assignment excluding graphs, figure legends and references should be no more than 1000 words. The % of marks allocated to each section is a guide to the word length for that section. Where appropriate references should be included using the Harvard System cited appropriately in the text with correct formatting in the reference list. As a guide a minimum of 4 but no more than about 12 references should be used. You are advised to use references from both primary and secondary sources.
Assignments should be typed and submitted using learnonline via the Course Website. Graphs must be thoughtfully incorporated into the text.
1. Why is the disease given the name diabetes mellitus? How does diabetes mellitus differ from diabetes insipidus?
2. Individuals with the diabetes mellitus are classified into two main groups. What are they and what is the basis of the classification system used?
3. How are patients diagnosed as diabetics? What treatment options are most used to manage this condition?
4. What changes in the metabolism of glucose and fat (triglycerides) are observed in this disease? What symptoms might a diabetic show as a result of these metabolic changes and why do these occur?
5. Two overnight fasting patients, A & B, were each given a dose of 75g of glucose at time zero. Their blood glucose levels were measured at 0, 30, 60, 90, 120 and 240 minutes after ingestion of the glucose using a glucose specific assay. The brief procedure for this assay is:-
a. Add 5.0 ml of assay reagent to sufficient tubes for the assay
b. Add 0. 1 ml of each glucose standard to a tube of assay reagent
c. Add 0. 1 ml of each test serum to a tube of assay reagent.
d. Mix the contents of each tube and read the absorbance at 625 nm.
The results obtained are shown in the two tables below.
Table 1 - standards
|
Glucose standard (mmol/L)
|
Absorbance @ 625 nm
|
|
0
|
0.02
|
|
3
|
0.21
|
|
6
|
0.43
|
|
9
|
0.65
|
|
12
|
0.83
|
Table 2 - patient results
|
Time (min)
|
Absorbance-Patient A
|
Absorbance-Patient B
|
|
0
|
0.26
|
0.47
|
|
30
|
0.51
|
0.63
|
|
60
|
0.25
|
0.80
|
|
90
|
0.23
|
0.76
|
|
120
|
0.24
|
0.63
|
|
240
|
0.30
|
0.58
|
Plot a standard graph of absorbance at 625 nm against glucose concentration You must use Excel.
Determine the concentration of glucose in each patient serum sample and plot glucose concentration against the time over which the samples were obtained.
Comment on the results for the two patients
6. What potential long term problems would a pharmacist need to be aware of when advising a diabetic client?