Consumption of puffer fish is often deadly. This is because of ingestion of a virulent poison tetradotoxin (TTX) that is concentrated in fish organs. TTX selectively binds to voltage-dependent sodium channels and blocks the channel. Consequently, this will:
A) inhibit generation of actiaon potential (AP) and inhibit transmitter release from neurons
B) hyperpolarize neurons
C) depolarize neurons
D) prolong duration of AP and inhibit transmitter release from neurons