Consider a circular b form dna molecule with a superhelical, Ask an Expert

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Consider a circular, B form DNA molecule with a superhelical density of -0.05. Suppose that during replication initiation, a stretch of 84 base pairs unwinds (untwists) without breaking the phosphodiester backbone. What will be the effect on the linking number (Lk) and the writhe (Wr)? (Hint: ‘untwisting' has a negative effect on the twist).

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