Conservative substitution the nucleotide mutation that, Ask an Expert

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Conservative Substitution: The nucleotide mutation that alters the amino acid sequence of protein, but which causes substitution of one amino acid with another which has a side chain with the similar charge/polarity characteristics. The size of the side chain might also be a significant consideration. Conservative mutations are usually considered unlikely to profoundly alter the structure or the function of a protein, but there are number of exceptions.

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