Ask Question, Ask an Expert

+1-415-315-9853

info@mywordsolution.com

Ask Biology Expert

Connecting the Concepts – Assignment #1

Required Reading and Materials:

Bissell, M.J. and Hines, W.C. (2011) Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nature Medicine;17(3):320-9.

TED Talk: Mina Bissell, In Cancer Context is Critical (2012). http://www.ted.com/talks/mina_bissell_experiments_that_point_to_a_new_understanding_of_cancer.html

Assignment Format – essay or presentation option (CHOOSE ONE):

Essay option: prepare a 3 – 5 page essay (double spaced, 1 inch margins, 12 point font) to answer one of the problems below. Include at least 3 scholarly references. Please submit your essay to turnitin.com by midnight on Feb. 22nd.

Presentation option: Assemble a 10 – 12 slide powerpoint presentation (excluding the title slide and reference slide) to address one of the problems below (as if you were giving a lecture). Each slide should include at least one relevant image to assist in your explanation of the topic. If you choose this option, you must also submit a brief 1 page synopsis of your presentation. Include at least 3 scholarly references (images should be referenced as well). Please submit the one page synopsis to turnitin.com by midnight on Feb. 22nd.

Note: This assignment is based on very “big picture” problems, and I do not expect you to provide an extremely detailed, expert view on this topic. The goal of this assignment is to present your understanding of a key concept in cancer biology in an organized and thoughtful manner. This will most likely require you to read and consider more information than you will ultimately discuss. As a graduate student, this is an important skill (to review and analyze a variety of sources surrounding a central topic, then provide a well-informed - but relatively brief - perspective on a focused topic). The bottom line is, you will not be able to discuss everything. Choose several main concepts as your focus, and work to connect these ideas for your audience.

Assignment problems (CHOOSE ONE):

In the first four chapters, we have learned about the classification of various types of cancer, the nature of cancer (hallmarks of cancer, environmental contributions to cancer, and altered metabolism), and early work with tumor viruses that paved to the way to approaching cancer biology from a molecular/genetic perspective. The review by Bissell and Hines adds an additional perspective to our current understanding of cancer – the role of the tumor microenvironment.

The goal for “Connecting the Concepts – Assignment #1” is to integrate these topics to discuss a comprehensive view of the nature of cancer.

Choose ONE of the following problems for this assignment:

1. The Mystery of Tissue Specificity. As a result of advanced genetic and molecular techniques, many germline mutations (inherited mutations passed down to offspring as opposed to somatic mutations acquired during the adult lifetime) associated with an increased risk of developing cancer have been identified (see the COSMIC database, germline mutations for a complete list here): http://cancer.sanger.ac.uk/cosmic/census/tables?name=gmuts.

Choose one germline mutation as your topic focus. Discuss the normal function of the gene as well as the role of the mutated gene in cancer development and/or progression, the type of cancer(s) associated with this mutation (keeping in mind classifications from Ch. 2), and the role of the tumor microenvironment in the development and/or progression of the specific cancer discussed. If specific information is not available on the influence of the microenvironment on this particular tumor type, provide informed speculation based on your reading.

2. Tumor viruses.

Choose a well characterized tumor virus as your topic focus (note: you may choose a virus that infects either humans or animals). Discuss the nature of the virus, the type of cancer(s) associated with this virus (keeping in mind classifications from Ch. 2), the role of the virus in tumor formation and/or progression, and the role of environment/microenvironment in the development of the virus-associated cancer. More specifically, being infected with a tumor causing virus does not guarantee the development of cancer (for ex, HPV infection and cervical cancer). What environmental factors influence the risk of developing cancer if infected with this virus? If specific information is not available on the influence of environmental/microenvironmental factors on this particular virus-associated tumor type, provide informed speculation based on your reading.

Biology, Academics

  • Category:- Biology
  • Reference No.:- M914441
  • Price:- $40

Priced at Now at $40, Verified Solution

Have any Question? 


Related Questions in Biology

Describe two relic structures in mans anatomy that reflect

Describe two relic structures in man's anatomy that reflect our common evolution history with animals.

In essay form a identify discuss and explain at least 4

In essay form a) Identify, discuss and explain at least 4 actions that can result in changes in chromosome structure. b) Explain why changes in nucleotide sequence could result in the production of different proteins. Be ...

Topic 1 discussion topiclist four areas of negligence for

Topic 1: Discussion topic List four areas of negligence for allied health professionals. Discuss the standard of care in each area, and how that standard can be applied to the healthcare facility.

Over half of the bodys glucose is metabolized in the brain

Over half of the body's glucose is metabolized in the brain. Very few of the alternate fuels are used in the brain, but are commonly used by other parts of the body. Muscles increase their use of glucose with increasing ...

We all see animals in our day to day lives choose a

We all see animals in our day to day lives. Choose a behavior you saw exhibited by an animal. Explain your thoughts on the potential proximate and ultimate causes of the behavior.

Discussion topicolder people die for a number of reasons

Discussion Topic Older people die for a number of reasons: cancer, heart failure, complications due to diabetes, stroke, Alzheimer's, etc. Often times, the way we live our lives affect not only how long we live but what ...

How does sexual reproduction benefit the offspring in

How does sexual reproduction benefit the offspring in terms of genetic variation? Provide an example

Give an example of pairs that can be mixed together to make

Give an example of pairs that can be mixed together to make a budget solution?

Microbiology1 for what specific purpose was gram staining

Microbiology 1. For what specific purpose was gram staining developed for? what is it used for today? 2. Why is the presence of air bubbles a sign of contamination? 3. Why is a gram stain helpful when monitoring bacteria ...

Name a process that occurs when dna is released by a broken

Name a process that occurs when DNA is released by a broken or lysed bacterium is taken up by another bacterium through its cell membrane giving this bacterium new traits

  • 4,153,160 Questions Asked
  • 13,132 Experts
  • 2,558,936 Questions Answered

Ask Experts for help!!

Looking for Assignment Help?

Start excelling in your Courses, Get help with Assignment

Write us your full requirement for evaluation and you will receive response within 20 minutes turnaround time.

Ask Now Help with Problems, Get a Best Answer

WalMart Identification of theory and critical discussion

Drawing on the prescribed text and/or relevant academic literature, produce a paper which discusses the nature of group

Section onea in an atwood machine suppose two objects of

SECTION ONE (a) In an Atwood Machine, suppose two objects of unequal mass are hung vertically over a frictionless

Part 1you work in hr for a company that operates a factory

Part 1: You work in HR for a company that operates a factory manufacturing fiberglass. There are several hundred empl

Details on advanced accounting paperthis paper is intended

DETAILS ON ADVANCED ACCOUNTING PAPER This paper is intended for students to apply the theoretical knowledge around ac

Create a provider database and related reports and queries

Create a provider database and related reports and queries to capture contact information for potential PC component pro