At the cardiovascular/tissue interface, which one of the following will occur under normal conditions?

A. the loading of O2 onto hemoglobin forces the unloading of CO2 into the tissues

B. the loading of CO2 onto hemoglobin forces the unloading of CO2 into the tissues

C. the loading of CO2 onto hemoglobin forces the unloading of carbaminohemoglobin into the tissues

D. the loading of O2 onto globin forces the unloading of CO2 into the tissues

E. the loading of CO2 onto globin forces the unloading of O2 into the tissues