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At 1 AM, a researcher places a healthy squid giant axon in a bath of normal squid physiological extracellular saline and internally perfuses the axon with normal squid intracellular saline. 

Its resting potential at 1:55 AM is -70 millivolts.  For this question, ignore any possible effects due to the sodium-potassium pump.  At 2 AM, the researcher replaces both the intracellular and the extracellular salines.

A. In the 2 AM intracellular perfusion saline, the concentration of potassium ion is decreased; in the 2 AM extracellular saline, the concentration of potassium ion is not changed.  This will cause an increase in the Nernst equilibrium potential for potassium ion.

B. In the 2 AM intracellular perfusion saline, the concentration of potassium ion is decreased; in the 2 AM extracellular saline, the concentration of potassium ion is not changed.  This will cause a decrease in the resting membrane voltage.

C. In the 2 AM extracellular saline, the concentration of potassium ion is increased; in the 2 AM intracellular perfusion saline, the concentration of potassium ion is not changed.  This will cause a decrease in the Nernst equilibrium potential for potassium ion.

 

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