Although several different mammalian species have been, Ask an Expert

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Although several different mammalian species have been cloned, the efficiency of this process is extremely low. Often tens or even hundreds of oocytes must be implanted with donor nuclei to obtain one healthy live birth. Many researchers believe the difficulties with cloning reside in the epigenetic modifications, such as DNA methylation, that occur within various cells during an individual's life. How do you suspect such modifications might affect the success of an experiment?

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