Activation of metabotropic glutamate receptors in neurons is often coupled to the activation of phospolipase C (PLC). Activation of PLC-dependent signaling pathway leads to:
A) diacil glycerol formation and activation of protein kinase C that phosphorylates channels
B) generation of cyclic-AMP and protein kinase A activation that de-phosphorylates channels
C) intracellular calcium mobilization
D) both A and C