A woman with facioscapulohumeral muscular dystrophy (FMD), an autosomal dominant trait, is seeking advice on having children. FMD does not run in her family. Her husband, who is 28 and normal, has an uncle with Huntington's disease (HD; autosomal dominant). His parents are normal, and both are over 50. Symptoms of Huntington's disease may appear from 12 to 65 years after birth; however, all HD members of his father's kindred developed signs during their thirties. HD and FMD are fully penetrant. What are the genetic risks for this couple's children?
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