Ask Question, Ask an Expert

+1-415-315-9853

info@mywordsolution.com

Ask Biology Expert

A researcher newly discovered a mutant mouse with an interesting T cell phenotype. He called this new mutation: HD, bred the mouse and then used these founders to produce a strain homozygous for HD. Some of his finding is summarized in the table shown below:

1702_conducting mutant mouse experiment.jpg

Q1. What did he find?

Q2. He next made bone marrow chimeras, injecting bone marrow from HD mice to lethally irradiated wild type mice. They found that the thymocytes in such chimeras exhibited a staining pattern similar to that of HD mice. In contrast when they did the inverse, they found that the thymocytes exhibited a normalCD4/CD8 phenotype. What do such results tell you?

Q3. Based on such results, advance a hypothesis regarding the cause of the phenotype.

Q4. Based on your hypothesis, what do you forecast would happen to developing T cell in an HD mouse which has been made transgenic for a TCR restricted to I- Ab. Describe your reasoning.

Biology, Academics

  • Category:- Biology
  • Reference No.:- M99638

Have any Question? 


Related Questions in Biology

Which phylloclade commonly found in xerophytic plants that

Which phylloclade commonly found in xerophytic plants that is modified?

One more as soon as possible if you can please thank youthe

One more, as soon as possible if you can please! Thank you The technical advances covered in Chapter 15 are creating a host of medical and moral issues that we will all have to confront. Briefly discuss the four major as ...

1 describe the three classes of carcinogens and their sub

1. Describe the three classes of carcinogens and their sub classes; describe the role each plays in the cancer process and give chemical examples. 2. Describe six points in the cancer process where the process can be inh ...

What arises from flask-shaped cylindrical structures known

What arises from flask-shaped cylindrical structures known as phialides?

Given what you know about how natural selection works

Given what you know about how Natural Selection works, explain why Sickle cell disease hasn't been eradicated from the population.

Discuss five different techniques used in the preparation

Discuss five different techniques used in the preparation of fermented products. please cite where you got the information please.

How do gap junctions function with the intercellular

How do gap junctions function with the intercellular diffusion of sodium

What type of reproduction involves union of sex cells and

What type of reproduction involves union of sex cells and their nuclei?

Wellnesssynthesize in about 250 words an overview of what

Wellness Synthesize, in about 250 words, an overview of what you have learned from the course with regard to health and wellness. How do the various aspects of wellness influence one another? How do different disciplines ...

A man and a woman both have polydactyly ie six fingers on

A man and a woman both have polydactyly (i.e., six fingers on each hand), a trait which is determined in this example by a single gene. They have four children, none of whom have polydactyly. What is the probability thei ...

  • 4,153,160 Questions Asked
  • 13,132 Experts
  • 2,558,936 Questions Answered

Ask Experts for help!!

Looking for Assignment Help?

Start excelling in your Courses, Get help with Assignment

Write us your full requirement for evaluation and you will receive response within 20 minutes turnaround time.

Ask Now Help with Problems, Get a Best Answer

Section onea in an atwood machine suppose two objects of

SECTION ONE (a) In an Atwood Machine, suppose two objects of unequal mass are hung vertically over a frictionless

Part 1you work in hr for a company that operates a factory

Part 1: You work in HR for a company that operates a factory manufacturing fiberglass. There are several hundred empl

Details on advanced accounting paperthis paper is intended

DETAILS ON ADVANCED ACCOUNTING PAPER This paper is intended for students to apply the theoretical knowledge around ac

Create a provider database and related reports and queries

Create a provider database and related reports and queries to capture contact information for potential PC component pro

Describe what you learned about the impact of economic

Describe what you learned about the impact of economic, social, and demographic trends affecting the US labor environmen