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Question: A karyotypically normal couple has a child with trisomy 21 Down syndrome. DNA analysis if 21q polymorphic markers reveals the following results. (Letters refer to polymorphic loci; numbers refer to alleles at that locus.) In which meiotic division did nondisjunction occur? Marker LocusFatherMother child A1, 22, 21, 2, 2 B1, 12, 21, 2, 2 C1, 11, 11, 1, 1 D1, 11, 21, 2, 2 (A)Maternal meiosis I (B)Maternal meiosis II (C)Paternal meiosis I (D)Paternal meiosis II (E)Paternal meiosis I or II

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