(Answered) 1 using temozolomide as a first new alkalating agent

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1. Using temozolomide as a first new alkalating agent approved for treatment of malignant gliomas describe its mechanism of action, clinical benefits and major site effects. Compare to other compounds with similar mechanism of action.

2. Present the comparison of clinical benefits of the use of antineoplastic drugs. What criteria are used for selection and for monitoring of most commonly used antineoplastic drugs?

3. Briefly present the mechanism of action of inhibitors of intracellular signaling used for antineoplastic therapy?

4. Give your insights regarding present and future of biological therapies for cancer treatment.

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