The CO₂ produced in one round of the citric acid cycle does not originate in the acetyl carbons that enter that round. Create a diagram of the TCA cycle to illustrate the answers to questions 1a and 1b.

a. If acetyl-CoA is labeled with ¹⁴C at its carbonyl carbon, how many rounds of the cycle are required to produce ¹⁴CO₂?

b. How many rounds if acetyl-CoA is ¹⁴C-labeled at its methyl group?

You must show the carbon cycling to get full credit.