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Problem: Checking the randomization. If the random assignment of patients to treatments did a good job of eliminating bias, possible lurking variables such as smoking history, asthma, and hay fever should be similar in all four groups. After recording and comparing many such variables, the investigators said that "all showed no significant difference between groups." Explain to someone who knows no statistics what "no significant difference" means. Does it mean that the presence of all these variables was exactly the same in all four treatment groups?

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