Given the discussion about compromises and debate over the issue of slavery from the time of the Constitution in 1788 to the Civil War in 1860-61, how would you tie together these events/agreements, and how would you argue that their onward trajectory at least in part lead to the issue of southern secession in 1860. (write at least 4-5 paragraphs.

-Compromises Made to Anti-Federalists in the Constitution (3/5 Clause, 1808 Extension of Atlantic Slavery, Fugitive Slave Clause, The Bill of Rights) 

-Missouri Compromise

-Compromise of 1850

-Kansas/Nebraska Act of 1854

-Dred Scott Case of 1857