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Four aldehydes and four hydrazines were used to explore hydrazone antibacterial activity in a combinatorial technique. How many reactions and antibiotic screenings would have been required to carry out this analysis in a non-combinatorial fashion? If we were interested in examining 50 different aldehydes and 50 different hydrazines, how many reactions and antibiotic screenings would be required to carry out this analysis in a non-combinatorial fashion? and how many using the combinatorial technique?

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