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Find an equation for d[P]/dt equivalent to the Michaelis-Menten equation when the third step of the reaction (Reaction R14.7) is not required to be fast compared to the second step, and when k-2 is significant. Assume only that both intermediates ES and EP are in steady-state concentrations and that the reaction is at early enough a stage that [P] 0. The equation should depend on the concentrations [E]0 and [S] and on the rate constants. Verify that your solution is consistent with the Michaelis-Menten equation in the appropriate limit.

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