1. Explain what is meant by Chousekeeping gene and why the gene for enolase is not considered a housekeeping gene despite it being expressed in all tissues.

2. The authors characterize enolase as a Cmoonlighting protein. Explain what this means and how it helps to explain the apparent paradox of finding enolase in organisms that do not use glycolysis for energy?

3. Druggability is a term used to describe the relative likelihood that a particular protein or enzyme will be a good target for small molecule