Draw the structure of histidine in each ionization state., Ask an Expert

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-A peptide has the sequence:

Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly

a. What is the net charge of the molecule at pH 4 and 11? (Use pKa values of those in the ppt)

b. What is the pI for the peptide?

-Histidine has three ionisable functional groups. Write the equilibrium equations for its three ionizations and assign the proper pKa for each ionization. Draw the structure of histidine in each ionization state. What is the net charge of the histidine molecule in each ionization state?

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Category:- Chemistry
Reference No.:- M9696132

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