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Consider the following acids and bases:

HCO2H, Ka=1.8x10-4

HONH2, Kb=1.1x10-8

HOBr, Ka=2.0x10-9

(C2H5)2NH, Kb=1.3x10-3

Which combination of the following substances would make the best choice to make a pH=6.0 buffer solution?

HOBr

KCO2

NaOBr

HONH2

(C2H5)2NH

HONH3NO3

(C2H5)2NH2Cl

HCO2H

A best buffer has approximately equal concentrations of weak acid and conjugate base (or weak base and conjugate acid). When [weak acid] = [conjugate base], then pH = pKa of the acid component of the buffer. Therefore, look for a weak acid/conjugate base pair or weak base/conjugate acid pair whose pKa value for the acid component in the buffer is close to the pH you want to make the buffer at.

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