1) prepare a brief note on the following:

a) PDB file format

b) STAR file format

c) CIF file format

d) mmCIF file format

2) describe how we can visualize 3D coordinate file a protein; describe several model of representing the small molecule or the crystal structure?

3) Discuss the database system involving the hierarchical database system, network model, relational model and the object based model?

4) describe what is meant by the crystallography databases, elaborate and describe the following terms:

a) ICSD

b) CSD

c) PDB

5) describe how can we synthesize the chemical molecules interest by the solid phase synthesis?

6) describe how can we synthesize the chemical molecules interest by the solution phase synthesis?

7) describe the meaning of the virtual screening describe its importance?

8) describe how you can develop the combinatorial library; prepare down the approaches of the optimization?

9) describe the ligand based drug designing (LBDD) in brief?

10) describe the term lead finding and the optimization?