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You have decided to have him stop the pseudoephedrine related to his hypertension, as well as the cimetidine related to its interaction with warfarin. The patient returns for his monthly follow-up appointment, and it is noticed that his blood pressure (195/80) has not come under control. You decide to start him on hydrochlorothiazide.

Is there a better medication than a thiazide, and if so what dose should you initiate this medication?

How would you proceed, and how you would monitor for efficacy and toxicity?

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