Written Assignment-

Background:  This virtual experiment is to characterise drugs affecting the contractility of the guinea pig ileum smooth muscle using the simulated program "Pharmacological Experiments on Isolated Guinea Pig Ileum". Students will be provided a set of raw experimental data to be used to complete the assignment task. Although the experimental data is generated using a simulation, students need to write their report reflecting a real-life laboratory experiment.

Aim: The aim of this assignment task is to evaluate the pharmacological effect and possible mechanism of action of the given test compound (NS-009) on the contractility of isolated guinea pig ileum following a systematic drug evaluation procedure. The agonist substances available for this evaluation are acetylcholine, histamine and barium chloride.

Assignment requirement:

Rationale - This assessment aims to assess student understanding of the methods and processes of drug valuation and to analyse the pharmacological actions and mechanisms of clinically used drugs at the receptor level.

Task - This is a virtual experiment to evaluate drugs that affect the smooth muscle contractility using a set of raw experimental data generated using a simulated computer program.

Criteria - You will be assessed on the following:

Title: Brief, clear, concise and informative. The title encapsulates what your report is about.

Abstract: Outlines in no more than 150 words the following areas. The abstract enables the reader to grasp the key points you have discovered, as well as briefly describing the aim(s), methodology, results and discussion.

Introduction: The introduction must move from the general to the specific. The introduction tells the reader in more detail, moving from the general to the specific, 'why this study is being done and ends with statement of overall aims/ objectives and test hypothesis'.

Materials and Methods: Clear, precise description of the experiment that is in enough detail to enable replication by another researcher. This section should be written in past tense third person and should NOT be in dot point format. This section, precisely describes the methods/materials/data use, to complete the study, in enough detail to enable someone else to repeat the exact procedure/study

Results: Clear, precise description of the findings. This section describes but does not explain the results. It provides a factual account of the findings, for example trends/outcomes noted but not discussed

Discussion: An informed commentary based on the actual results. This is where to add any explanations of what the data means. i.e. What do the results tell? This section must relate the results back to the literature and finally form a conclusion. This section tells the reader what the results mean in terms of the context/background literature/related research and the test hypothesis. Like the introduction, it moves from the general to specific in the discussion of each result-how does this result support/inform the literature/test hypothesis.

References/grammar check/format (Harvard referencing style required throughout see the University library website)

Assignment Format:

• The assignment has to be in the form of a scientific report with the following sections.
• Title
• Abstract
• Introduction
• Methods
• Results
• Discussion
• References.

Attachment:- Assignment.rar