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Which of the following statements does not demonstrate the highly reinforcing effects of opiates?

a. Animals readily self-administer all known opiate agonist drugs.

b. Opiates are the most effective pain-reducing drugs available to physicians.

c. The chronic use of opiates often leads to tolerance and physical dependence.

d. Naloxone blocks the effects of opiate self-injection.

e. Opiate drugs have medicinal use but also great potential for abuse.

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