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What is Act on incretin hormone to indirectly effect insulin production

Monotherapy and Combination Therapy

Sitagliptin (Januvia) and Saxagliptin (Onglyza)

Well tolerated, low risk for hypoglycemia, do not cause weight gain

Caution with renal impairment

Need serum Cr and CCr prior to admin

Pregnancy Category B, need to be using insulin; Do not use in breastfeeding

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