Based on what you learned about genome editing technologies and the application of the tool to medical research and medicine, research and develop an idea for using CRISPR-cas9 or related technologies for some clinical purpose (i.e., a model for a disease, an assay for diagnosis or drug development, a gene therapy).

Prepare a 3-5 page whitepaper, describing a proposed application of genome editing technologies to a clinical development (i.e., a cell culture or animal model for studying a disease, an diagnostic or research assay, or a gene therapy).

Pretend that the audience for your whitepaper of the technology are senior administrators in a funding institution who might fund your project. Your job is to sell your project.

Answer the following questions, based on the Heilmier Catechism, in your whitepaper:

1. What are you trying to do? Articulate your objectives using absolutely no jargon. What is the problem? Why is it hard?

2. How is it done today, and what are the limits of current practice?

3. What's new in your approach and why do you think it will be successful?

4. Who cares? And why do they care?

5. If you're successful, what difference will it make? What impact will success have? How will success be measured?

6. What are the risks and the payoffs?