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Task 1:

The effect of a hazardous substance depends on the concentration of the substance that is present in the body’s systems. The concentration depends on the stages of toxicokinetics.

Required:

problem1. What are the four major phases of toxicokinetics?

problem2. What are the major objectives and aims of xenobiotic metabolism?

problem3. Describe in details the principles of biotransformation differentiating clearly the phases and stages involved. Exemplify your answer with appropriate instances.

problem4. In brief describe the four routes of excretion of hazardous substances from body?

problem5. Why is the concept of ‘half-life’ of substance significant?

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