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Q1. Suppose that, in the hypothetical study shown in the below table, cases underestimated their exposure and as a result, 20 percent of exposed cases were falsely categorized as unexposed, however that the categorization of controls was not influenced.

True outcomes of a hypothetical case-control study with no measurement Error

679_case control study.jpg

Is this kind of misclassification arbitrary or systematic? Is it differential or non-differential?

Q2. What effect would it encompass on the outcomes of the study? (In your answer draw up a two-by-two table showing the miss-classification, then compute estimates of the risk ratio for both the true and the misclassified outcomes and make comment on their difference to exemplify the effect).

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