problem 1) Structure and functions of biological membrane. Enlist different processes of drug transport across the biological membrane. describe in detail specialised transport.

problem2) Describe the fate of drugs. describe the role of microsomal enzyme system in biotransformation of drugs.

problem 3) Solve the following:

i) Describe the therapeutic index.

ii) describe about bioavailability of drugs.

iii) Describe the term antagonism with suitable exs.

iv) describe the first pass metabolism with suitable exs.

v) describe how various pathological states modifying drug action.

vi) describe the anaphylaxis.

vii) describe the placental barrier

problem 4) prepare a detailed note on the following:

i) G-protein coupled receptors (GPCR)

ii) Antiplatelet agents

iii) Drug treatment in pregnancy

iv) Fibric acid derivatives used as hypolipidimics

v) Types of gene therapy.

problem 5) Define and classify pneumonia. describe the etiology, complications and clinical features of bacterial pneumonia.

problem 6) describe cardiac arrhythmia. Discuss the pathophysiology of cardiac arrhythmia.

problem 7) Solve the following:

i) describe the pathophysiology of chronic renal failure.

ii) Describe the pathophysiology of pain.

iii) describe the pathophysiology of depression.

iv) Describe the etiology of malaria.

v) Pathophysiology of angina pectoris.

vi) Describe the complications of AIDS.

vii) Clinical features of type 1 and 2 diabetes mellitus.

problem 8) prepare a brief note on the following:

i) Psychosis

ii) Sexually transmitted diseases

iii) Allergy

iv) Amoebic dysentery

v) Myocardial ischemia.