Questions on Metabolic disorder Hyperuricemia associated with gout (references are needed for each) Answers should be given in paragraph form and in your own words.

1. Describe in details what is hyperuricemia with gout.

2. Describe in detail the symptoms of hyperuricemia with gout.

3. Who is affected by hyperuricemia with gout?

4. What factors lead to the development of hyperuricemia with gout?

5. How is hyperuricemia with gout diagnosed?

6. What are the causes of hyperuricemia with gout?

7.  Describe in detail the biochemical pathway involved in hyperuricemia with gout.  Explain with diagrams

8. For hyperuricemia with gout are there any genetic markers? If so explain what they are and how are they used?

9. Describe how any defects in the pathway or disregulation leads to hyperuricemia with gout.  Explain with diagram

10. Describe any mechanisms of action and the critical studies that lead to understanding of the mechanism.  Explain with diagram

11. What is the current treatment for hyperuricemia with gout?

12.  Is the treatment an inhibitor?

13. Does this molecule allosterically control a particular enzyme?

14. Are there biochemical markers involved?

15. Describe the specific biochemical reaction involved.

16. Describe the effect of any therapeutic on the biochemical pathway.  Explain with diagram.

17.  What can be concluded about hyperuricemia with gout?