· Explain the importance of the problem or critical barrier to progress in the field that the proposed project addresses.

· Explain how the proposed project improves scientific knowledge, technical capability, and/or clinical practice in one or more broad fields.

· Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field may change if the proposed aims are achieved.

· Explain how the application challenges and seeks to shift current research or clinical practice paradigms.

· Describe any novel theoretical concepts, approaches or methodologies, instrumentation or intervention(s) to be developed or used, and any advantage over existing methodologies, instrumentation or intervention(s).

· Explain any refinements, improvements, or new applications of theoretical concepts, approaches or methodologies, instrumentation or interventions.

· Describe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project. Include how the data will be collected, analyzed, and interpreted.

· Discuss potential problems, alternative strategies, and benchmarks for success anticipated to achieve the aims.

· Describe strategies to establish feasibility, and address the management of any high-risk aspects of the proposed work.