I need help with creating five PICOT questions for Literature review of project related to Critical low INR or blood clot. This is what I come up.

1. In a patient with a blood clot or critical low INR values, what is an effective way of screening comparing to the current screening method?

2. What can be done to prevent to avoid critical low INR values to occur again?

3. Patient with critically low INR values or blood clot what is the clinical outcome?

4. How can we implement interventions and treatment for this critical INR values?

5. How can we prevent this issue not to occur again?