I have been taking zoloft since I was 17 1/2 years old and will be 21 soon. I am no where depressed at all anymore but continue taking the medicine. I had been taking 100mg but decreased to 75mg in august and recently started taking only 50mg in December. I am very intune with my body and just wondering if this is has caused fatigue for others? Please post your experiences and how you have overcome the fatigue. Has zoloft(seratraline)caused extreme fatigue for anyone after prolonged usage?