I have been taking Fluoxetine 40mg and Trazadone 100mg for about 2 years. A month ago I had a bout of major depression and was in the hospital. My PMD started me on lamotrigine for Bipolar. I recently had a manic episode and was told to stop taking the Fluoxetine and Trazadone and start Seroquel. I am always nervous about stating a new medication. I know that everyone reacts different to meds., but I was curious about the side effects people have experienced. I also am not thrilled about the weight gain. I also wondered about anxiety, since I don't think either of my current meds help that.