Husband was diagnosed with CLL a year ago, refused chemo at, Ask an Expert

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Husband was diagnosed with CLL a year ago, refused chemo at first, but got hospitalized in May with ex tensive pleural effusion. They put a pleural catheter(over 3l was drained).HGB was 5.5.WBC over 200000.He was put on chemotherapy, but did 2 treatments out of 6, as his doctor thought it ineffective.WBC is 22 now and HGB is 8.5. 3 weeks ago doctor put him on Imbruvica, 420mg daily.No side effects and WBC and HGB still the same.but the pleural effusion increased- every third day it's 600-800cc. My question is. Can taking imbruvica increase the volume of pleural effusion, and if so, what to expect?

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