Headaches are much more severe than when on full Chemotherapy regimen. Avastin treatment received via infusion every two weeks for maintenance therapy (sole medication in current therapy.) Have had four treatments and each time headache as side effect is more severe - cumulative? Are triptans or other migraine medications effective and safe to use with Avastin? How to treat headache caused by bevacizumab? Occurs immediately after infusion & lasts 3-4 days?