Describe the metabolism of ifosfamide in comparison to cyclophosphamide using structures and a short paragraph. Which one would you expect to be more toxic (350 words)fosfamide and cyclophosphamide. Both share the same mechanism of action by alkylating DNA but their metabolism is different. You will have to do some research to investigate the metabolic routes, especially the involved enzymes, to determine if and which drug is more toxic.

Choose a newly introduced anti-neoplastic agent that is derived from a marine natural source and describe briefly its mechanism of action, metabolic pathways, and toxic side effects( 350 words) This question asks you to investigate a growing and diverse resource for drug discovery - marine natural products that have been found to be potential new lead drugs for chemotherapeutic agents. Pick one such drug and describe its structure, mechanism of action, and if it could serve as a potential lead for clinical investigations.