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1) Why are the lungs an important route of entry for toxicants? In your discussion, include how toxicants enter the blood stream through the lungs, and include how particles are removed from the lungs.

2) Explain how body water and volume of distribution affect the distribution of a chemical.

3) Explain the importance of phase 2 reactions. Include three examples of phase two reactions and a brief discussion for each.

4) Explain the importance of the cytochrome P-450 enzyme in toxicant biotransformation.

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