After taking Kapake for 5 years with no problems my GP changed to Solpodol. This coincided with house move and onset of sever diarrhea . I suffered 2 years before discovering it was the Solpodol and when Kapake was reintroduced I have been fine. Now my GP insists on changing it to Zapain. It consists of many of the same ingredients as Solpodol (not in Kapake). I am very fearful of the change but no research leads me to which ingredient causes the diarrhea. I suspect the talc but have no proof.