A significant polymorphic inversion on chromosome 17 the, Ask an Expert

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A significant polymorphic inversion on chromosome 17, the MAPT inversion, is identified by marker SNPs that can now be used to screen large numbers in a population. The inverted region is large and extends for approximately 900 kb. The two haplotypes (one inverted and one not) are each associated with increased risk of a number of neurological conditions. How can the inverted region be used to find the most recent common ancestor of the inversion?

A) by typing SNPs from humans and from other primates

B) by assessing SNPs from a large number of human populations

C) by looking for heterozygotes for the two kinds of chromosome 17

D) by fertility studies on populations with each of the haplotypes

E) by using a BAC clone library to identify the ends of the inversion

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