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A drug has a VD of 1 L/kg. A 50 kg man is given an IV bolus of this drug, and unfortunately the dose administered results in a CP above the toxic threshold. The C0 is determined to be at a concentration on 23 mg/L. If the drug has a t1/2 of 90 minutes, how long until the CP reaches the therapeutic and thus non-toxic dose of 3.0 mg/l?

What was the initial dose given to the patient?

What would have been the proper loading dose for a CP of 3.0 mg/L?

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