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A 54 year of age male presents with sad mood, anhedonia, lethargy, and suicidal ideation. Based on the information provided which of the following medications would you definitely avoid?

1) Fluoxetine (Prozac)

2) Imipramine (Tofranil)

3) Sertraline (Zoloft)

4) Bupropion (Wellbutrin)

5) 2 and 4

What is the rationale for your choice?

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