The standard screening test for downs syndrome is based on, Ask an Expert

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The standard screening test for Down's syndrome is based on a combination of maternal age and the level of serum alpha fetoprotein. Using the test 80% of Down's syndrome cases can be identified while 5% of normals are detected as positives.

What is the sensitivity and specificity of the test? Suppose that 1 out of 500 infants are born with Down's syndrome.

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