A clinical trial is conducted comparing a new pain reliever for arthritis to a placebo. Participants are randomly assigned to receive the new treatment or a placebo. The outcome is pain relief within 30 minutes. The data are shown in table:

                            Pain relief    no Pain relief
New medication       44                    76
Placebo                    21                    99

Is there a significant difference in the proportions of patients reporting pain relief?

Run the test at a 5% level of significance.