In 1947, the Framingham Study (Kannel, Dawber, Kagan, Revotskie7 &. Stokes, 1961) examined the development of heart disease in healthy volunteers. Since then, it has provided many insights into the risk: factors for various types of heart disease.
This discussion exercise considers data from one of its earliest published reports.
Table 6 in the original published report describes the Incidence of coronary heart disease (CHD) after six years of follow-up in men and women who were 40-59 years old at the time of their Initial examination.
The data for men is summarized as follows
- Of the 454 men in this age group with initial cholesterol levels less than 21O mg/dL (low serum cholesterol group), there were 16 CHD onsets.
- Of the 455 men in this age group with serum cholesterol levels between 21O and 244 mg/dL (intermediate serum cholesterol group), there were 16 CHD onsets.
- Of the 424 men in this age group with cholesterol -values of at least 245 mg/dL (high serum cholesterol group), there were 51 CHD onsets.
Using the data for men calculate the risk or Incidence proportion of developing CHD by cholesterol level
- Denote the 6-year risk of CHD In the low serum cholesterol group with the symbolP0
- Denote the 6-year risk of CHD in the intermediate serum cholesterol group with the symbolP1.
- Denote the 6-year risk of CHD In the high serum cholesterol group with the symbolP2
Calculate the incidence proportion or the risk ratio that compares group 1 to group 0, and calculate the Incidence proportion or the risk ratio that compares group 2 to group 0. Then post a summary of your findings.