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A randomised controlled trial (RCT) is being conducted to find out whether palliative care improves the mental health of people with advanced HIV. The study also measures age group, gender, time since HIV diagnosis, presence of physical, and s and pain, a socio-economic status. Mental health is measured from 100, and decimals ar possible (e.g. 55.7). Symptoms and pain are recorded from 0=none to 5=overw Iming, using whole numbers only.

i. What is the primary outcome or of study?

ii. What kind of variable is the primary outcome?

iii. Name:

• An independent (or exposure) binary variable
• An independent ordered categorical (or ordinal) Ctaribble
• An independent continuous variable

iv. What are the secondary outcomes and what kind of variables Wthey?

The RCT will includel120 people. After 30 were recruited, some early Analysis was carried-out. Here are the results using symptom score:

893_Draw box and whisker plots.png

v. Draw box and whisker plots of the data in Table 1

vi. Do you think the symptoms in the two groups are different? Explain your reasoning.

vii. What statistical test would you use to look for a difference between the groups?

viii. Why would you use this test, and are there any disadvantages of using it? You run the test with 5% significance. The test parameter is 11.5 and p=0.12.

ix. What does 5% significance mean?

x. Explain what p=0.12 means in this context as fully as possible.

xi. Why do you think a study design might include early analysis like this before the full sample has been recruited?


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